wayneliuq/claude-skills

Design and genome-verify PCR + nested Sanger primers to validate CRISPR-Cas9 cutting at a gRNA locus (ICE / TIDE / amplicon-NGS)

Coding discipline as seven independent outcome-based gates rather than a workflow: scope-gate, build-gate, cut-gate (47-shape bloat catalog tiered by blast radius, plus a two-question test-value rule; the one gate that edits, logging every finding before it touches anything), done-gate, bug-gate (18-shape bug catalog, findings tiered proven / traced / suspected), ship-gate, watch-gate — plus adversarial-delegation for running a gate over a worker you review rather than trust, over a shared canon of five first principles and a six-rule security spine. Each gate produces a verdict with evidence and admits gaps explicitly.